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Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy

Molecular Mechanisms and Clinical Applications

Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a central element of many treatment regimens. Cisplatin is still an irreplaceable component of a regimen that produces high cure rates in even advanced nonseminomatous germ-cell cancers, and is widely used in the treatment of ovarian cancers and other gynecologic cancers, head and neck, and numerous other tumor types. The development of carboplatin has reduced some of the adverse events associated with cisplatin treatment, and the introduction of the DACH platinum compound oxaliplatin has broadened the spectrum of activity of the platinums to include gastro-intestinal cancers, especially colorectal cancer. The clinical importance of this family of drugs continues to drive investigation into how these drugs work and how to improve their efficacy and reduce their toxicity. The papers in this volume were presented in Verona, Italy, during the tenth International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy. The symposium was jointly organized by the Department of Oncology of the Mater Salutis Hospital – Azienda Sanitaria Locale 21 of the Veneto Region – and by the Department of Medicine and Public Health, Section of Pharmacology, the University of Verona. They reflect the vitality of this field and the increasing use of new molecular and cell biologic, genetic, and biochemical tools to identify approaches to further improve their use.

This is the Tenth Symposium on Platinum and Other Metal Coordination
Compounds in Cancer Chemotherapy, and its highlights provide further
confirmation of the value of scientific investment in this area of therapeutic
research. Keywords ...

Hoyle's Modern Encyclopedia of Card Games

Rules of All the Basic Games and Popular Variations

The many varieties of poker, solitaire, pinochle, and rummy are included in this cross-referenced guide to all games

The many varieties of poker, solitaire, pinochle, and rummy are included in this cross-referenced guide to all games

Analisis dan Perancangan Sistem Informasi Manajemen Keuangan Daerah

Notasi Pemodelan Unified Modeling Language (UML)

Buku persembahan penerbit AbdiSistematika ini disusun salah satunya untuk menjawab tentang perlunya panduan praktis analisis dan perancangan Sistem Informasi Manajemen Keuangan Daerah. Penulis melakukan terobosan dengan menggunakan notasi pemodelan Unified Modeling Language (UML). UML adalah sebuah bahasa untuk menspesifikasikan, memvisualisasikan, merancang dan mendokumentasikan perangkat sistem software yang baik untuk pemodelan bisnis dan sistem lainnya selain software. UML merepresentasikan sebuah pengumpulan praktek rekayasa terbaik yang telah terbukti sukses dalam pemodelan sistem yang kompleks dan besar. UML menawarkan sebuah standar untuk merancang model sebuah sistem. -Abdi Sistematika- #Unpad #60thFEBUnpad

Buku persembahan penerbit AbdiSistematika ini disusun salah satunya untuk menjawab tentang perlunya panduan praktis analisis dan perancangan Sistem Informasi Manajemen Keuangan Daerah.

Study Guide for Mankiw's Essentials of Economics

David R. Hakes (University of Northern Iowa) has prepared a study guide that will enhance student success. Each chapter of the study guide includes learning objectives, a description of the chapter's context and purpose, a chapter review, key terms and definitions, advanced critical thinking questions, and helpful hints for understanding difficult concepts. Students can develop their understanding by doing the practice problems and short answer question, then assess their mastery of the key concepts with the self-test, which includes true/false and multiple choice questions.

Each chapter of the study guide includes learning objectives, a description of the chapter's context and purpose, a chapter review, key terms and definitions, advanced critical thinking questions, and helpful hints for understanding ...

Jejak langkah satu dasawarsa mengawal konstitusi, 2003-2013

Historical development of the Indonesian Constitutional Court, 2003-2013; volume commemorating the 10th anniversary of the Court.

Historical development of the Indonesian Constitutional Court, 2003-2013; volume commemorating the 10th anniversary of the Court.